Article
Identification of somatic gene mutations in penile squamous cell carcinoma.
Genes, chromosomes & cancer - 1 Oct 2015
Ferrándiz-Pulido Carla, Hernández-Losa Javier, Masferrer Emili, Vivancos Ana, Somoza Rosa, Marés Roso, Valverde Claudia, Salvador Carlos, Placer Jose, Morote Juan, Pujol Ramon M, Ramon y Cajal Santiago, de Torres Ines, Toll Agusti, García-Patos Vicente
Abstract excerpt
There is a lack of studies on somatic gene mutations and cell signaling driving penile carcinogenesis. Our objective was to analyze somatic mutations in genes downstream of EGFR in penile squamous cell carcinomas, especially the mTOR and RAS/MAPK pathways. We retrospectively analyzed somatic mutations in 10 in situ and 65 invasive penile squamous cell carcinomas by using Sequenom's Mass Spectrometry iPlex...
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