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Article

Somatic Mutation Profiling in Premalignant Lesions of Vulvar Squamous Cell Carcinoma.

International journal of molecular sciences - 10 Jul 2020

Zięba Sebastian, Pouwer Anne-Floor W, Kowalik Artur, Zalewski Kamil, Rusetska Natalia, Bakuła-Zalewska Elwira, Kopczyński Janusz, Pijnenborg Johanna M A, de Hullu Joanne A, Kowalewska Magdalena

Abstract excerpt

Vulvar squamous cell carcinoma (VSCC) originates from the progression of either a high-grade squamous intraepithelial lesion (HSIL) or differentiated-type vulvar intraepithelial neoplasia (dVIN), often in a background of lichen sclerosus (LS). The mechanisms leading to the progression of these premalignant lesions to VSCC are elusive. This study aims to identify pathogenic mutations implicated in VSCC...

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Identifiers

PMID: 32664330
DOI: 10.3390/ijms21144880
PMCID: PMC7402303

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