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Comprehensive genomic profiling of penile squamous cell carcinoma and the impact of human papillomavirus status on immune-checkpoint inhibitor-related biomarkers.

Cancer - 15 Dec 2023

Nazha Bassel, Zhuang Tony, Wu Sharon, Brown Jacqueline T, Magee Daniel, Carthon Bradley C, Kucuk Omer, Nabhan Chadi, Barata Pedro C, Heath Elisabeth I, Ryan Charles J, McKay Rana R, Master Viraj A, Bilen Mehmet Asim

Abstract excerpt

BACKGROUND: Advanced penile squamous cell carcinoma (pSCC) is a rare and aggressive malignancy with limited success of immune-checkpoint inhibitors (ICIs). Approximately half of pSCC cases are associated with human papillomavirus (HPV) infection. METHODS: Evaluation was done retrospectively of the landscape of somatic alterations and ICI-related biomarkers in pSCC by using the Caris Life Sciences data set with...

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B7-H1 Antigen
Human papillomavirus 16
Human papillomavirus 18
Human Papillomavirus Viruses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immune Checkpoint Inhibitors

Neoplastic Syndromes, Hereditary

Papillomavirus Infections

Penile Neoplasms

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PMID: 37565840
DOI: 10.1002/cncr.34982

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