Article
PIK3CA, HRAS and KRAS gene mutations in human penile cancer.
The Journal of urology - 1 May 2008
Andersson Patiyan, Kolaric Aleksandra, Windahl Torgny, Kirrander Peter, Söderkvist Peter, Karlsson Mats G
Abstract excerpt
PURPOSE: The knowledge of somatic mutations that arise in penile cancer is limited. We examined the dysregulation of components in the phosphatidylinositol 3-kinase and Ras pathways. MATERIALS AND METHODS: Using single stranded conformational analysis and direct sequencing we performed mutational analysis of the PIK3CA, PTEN, HRAS, KRAS, NRAS and BRAF genes in 28 penile tumors. RESULTS: We identified somatic...
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