Pathogenesis of Penile Squamous Cell Carcinoma: Molecular Update and Systematic Review.

doi:10.3390/ijms23010251

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Article

Pathogenesis of Penile Squamous Cell Carcinoma: Molecular Update and Systematic Review.

International journal of molecular sciences - 27 Dec 2021

Ribera-Cortada Inmaculada, Guerrero-Pineda José, Trias Isabel, Veloza Luis, Garcia Adriana, Marimon Lorena, Diaz-Mercedes Sherley, Alamo José Ramon, Rodrigo-Calvo Maria Teresa, Vega Naiara, López Del Campo Ricardo, Parra-Medina Rafael, Ajami Tarek, Martínez Antonio, Reig Oscar, Ribal Maria J, Corral-Molina Juan Manuel, Jares Pedro, Ordi Jaume, Rakislova Natalia

Abstract excerpt

Penile squamous cell carcinoma (PSCC) is a rare but aggressive neoplasm with dual pathogenesis (human papillomavirus (HPV)-associated and HPV-independent). The development of targeted treatment is hindered by poor knowledge of the molecular landscape of PSCC. We performed a thorough review of genetic alterations of PSCC focused on somatic mutations and/or copy number alterations. A total of seven articles have...

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PMID: 35008677
DOI: 10.3390/ijms23010251
PMCID: PMC8745288

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