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Article

Somatic mutation profiling of vulvar cancer: Exploring therapeutic targets.

Gynecologic oncology - 1 Sept 2018

Zięba Sebastian, Kowalik Artur, Zalewski Kamil, Rusetska Natalia, Goryca Krzysztof, Piaścik Agata, Misiek Marcin, Bakuła-Zalewska Elwira, Kopczyński Janusz, Kowalski Kamil, Radziszewski Jakub, Bidziński Mariusz, Góźdź Stanisław, Kowalewska Magdalena

Abstract excerpt

BACKGROUND: Vulvar squamous cell carcinoma (VSCC) constitutes over 90% of vulvar cancer. Its pathogenesis can follow two different pathways; high risk human papillomavirus (hrHPV)-dependent and HPV-independent. Due to the rarity of VSCC, molecular mechanisms underlying VSCC development remain largely unknown. The study aimed to identify pathogenic mutations implicated in the two pathways of VSCC development....

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Source

Identifiers

PMID: 29980281
DOI: 10.1016/j.ygyno.2018.06.026

Genes

AKT1
FGFR3
FLT3
GNAQ
HRAS
JAK3
PTEN
SMAD4
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Somatic mutation profiling of vulvar cancer: Exploring therapeutic targets.PMID 29980281Read ↗

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Identification of molecular targets in vulvar cancers.Semantic proximity Read ↗

Molecular Landscape of Vulvar Squamous Cell Carcinoma.Semantic proximity Read ↗

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Somatic Mutation Profiling in Premalignant Lesions of Vulvar Squamous Cell Carcinoma.Semantic proximity Read ↗

Vulvar Squamous Cell Carcinoma: Comprehensive Genomic Profiling of HPV+ Versus HPV– Forms Reveals Distinct Sets of Potentially Actionable Molecular TargetsSemantic proximity Read ↗

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