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Article

Identification of newly detected, drug-related HCMV UL97- and UL54-mutations using a modified plaque reduction assay.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Aug 2015

Fischer Lena, Sampaio Kerstin Laib, Jahn Gerhard, Hamprecht Klaus, Göhring Katharina

Abstract excerpt

BACKGROUND: Drug-resistant cytomegalovirus causes major problems in immunocompromised patients and is due to mutations in the UL97-gene (phosphotransferase) and/or the UL54-gene (polymerase). OBJECTIVE: Three previously unknown UL97-mutations (E596D/Y and I610T), one UL54 single point mutation (D515E) and a UL54 triple mutation (D515E+L516M+I521T) were characterized for drug-resistance by marker transfer analysis...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 26209398
DOI: 10.1016/j.jcv.2015.06.090

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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