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Article

Generation and characterization of a GCV resistant HCMV UL97-mutation and a drug sensitive UL54-mutation.

Antiviral research - 1 Dec 2013

Fischer Lena, Laib Sampaio Kerstin, Jahn Gerhard, Hamprecht Klaus, Göhring Katharina

Abstract excerpt

In transplant recipients, drug-resistant human cytomegalovirus (HCMV) infections remain a serious problem. Drug-resistance against ganciclovir (GCV), cidofovir (CDV) and foscarnet (PFA) is caused by mutations either in the phosphotransferase-gene (UL97) or in the viral polymerase (UL54). For characterization of newly emerging mutations marker transfer analysis is required. Two new HCMV-mutations, the...

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Identifiers

PMID: 24120366
DOI: 10.1016/j.antiviral.2013.09.026

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