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Article

Fluorescence-based assay for phenotypic characterization of human cytomegalovirus polymerase mutations regarding drug susceptibility and viral replicative fitness.

Antimicrobial agents and chemotherapy - 1 Sept 2009

Chevillotte Meike, Schubert Axel, Mertens Thomas, von Einem Jens

Abstract excerpt

One essential prerequisite for genotypic drug susceptibility testing of human cytomegalovirus (HCMV) is the phenotypic characterization of mutations identified in the viral protein kinase gene UL97 and the viral DNA polymerase gene UL54 regarding their quantitative impact on drug susceptibility. We developed a new method for phenotypic characterization of UL54 mutations with regard to polymerase activity, viral...

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Identifiers

PMID: 19546362
DOI: 10.1128/AAC.00165-09
PMCID: PMC2737853

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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