Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel DNA polymerase mutations conferring cytomegalovirus resistance: input of BAC-recombinant phenotyping and 3D model.

Antiviral research - 1 Apr 2013

Hantz Sébastien, Cotin Sébastien, Borst Eva, Couvreux Anthony, Salmier Arielle, Garrigue Isabelle, Merville Pierre, Mengelle Catherine, Attal Michel, Messerle Martin, Alain Sophie

Abstract excerpt

Long-term exposure to antiviral therapy in immunocompromised patients favors emergence of human cytomegalovirus (HCMV) resistance mutations. Two new UL54 DNA polymerase mutations (deletion of codon 524 and N408S substitution) identified in a kidney recipient and a bone marrow recipient respectively were characterized. Marker transfer experiment through recombination into a HCMV AD169 BAC demonstrated del524 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow Transplantation
Share to Chromosomes, Artificial, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytomegalovirus

Share to Cytomegalovirus Infections

Share to DNA-Directed DNA Polymerase

Share to Drug Resistance, Viral

Share to Kidney Transplantation

Share to Viral Proteins

Source

Identifiers

PMID: 23415883
DOI: 10.1016/j.antiviral.2013.02.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel DNA polymerase mutations conferring cytomegalovirus resistance: input of BAC-recombinant phenotyping and 3D model.PMID 23415883Read ↗

Contrasting effect of new HCMV pUL54 mutations on antiviral drug susceptibility: Benefits and limits of 3D analysis.Semantic proximity Read ↗

Phenotypic diversity of cytomegalovirus DNA polymerase gene variants observed after antiviral therapy.Semantic proximity Read ↗

Phenotyping of cytomegalovirus drug resistance mutations by using recombinant viruses incorporating a reporter gene.Semantic proximity Read ↗

Multidrug resistance conferred by novel DNA polymerase mutations in human cytomegalovirus isolates.Semantic proximity Read ↗

Identification of newly detected, drug-related HCMV UL97- and UL54-mutations using a modified plaque reduction assay.Semantic proximity Read ↗

Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments.Semantic proximity Read ↗

Genotypic and Phenotypic Study of Antiviral Resistance Mutations in Refractory Cytomegalovirus Infection.Semantic proximity Read ↗

Generation and characterization of a GCV resistant HCMV UL97-mutation and a drug sensitive UL54-mutation.Semantic proximity Read ↗

Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet.Semantic proximity Read ↗

Recombinant phenotyping of cytomegalovirus UL97 kinase sequence variants for ganciclovir resistance.Semantic proximity Read ↗

Improved detection of emerging drug-resistant mutant cytomegalovirus subpopulations by deep sequencing.Semantic proximity Read ↗

The biology of cytomegalovirus drug resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.