Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Recombinant phenotyping of cytomegalovirus UL97 kinase sequence variants for ganciclovir resistance.

Antimicrobial agents and chemotherapy - 1 Jun 2010

Chou Sunwen

Abstract excerpt

A strain of human cytomegalovirus, T2211, modified from standard laboratory strain AD169 to contain a secreted alkaline phosphatase reporter gene for rapid viral quantitation, was cloned as a bacterial artificial chromosome, BA1, and then mutagenized to create recombinant viruses containing viral UL97 kinase sequence variants found in clinical specimens after ganciclovir treatment, but with no phenotypic data to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Artificial, Bacterial
Share to Cytomegalovirus
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ganciclovir

Share to Genes, Viral

Share to In Vitro Techniques

Share to Mutagenesis

Share to Phosphotransferases (Alcohol Group Acceptor)

Source

Open in PubMed Open full text

Identifiers

PMID: 20385869
DOI: 10.1128/AAC.00186-10
PMCID: PMC2876423

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Recombinant phenotyping of cytomegalovirus UL97 kinase sequence variants for ganciclovir resistance.PMID 20385869Read ↗

Phenotyping of cytomegalovirus drug resistance mutations by using recombinant viruses incorporating a reporter gene.Semantic proximity Read ↗

Phenotypic diversity of cytomegalovirus DNA polymerase gene variants observed after antiviral therapy.Semantic proximity Read ↗

Growth and drug resistance phenotypes resulting from cytomegalovirus DNA polymerase region III mutations observed in clinical specimens.Semantic proximity Read ↗

Analysis of the UL97 phosphotransferase coding sequence in clinical cytomegalovirus isolates and identification of mutations conferring ganciclovir resistance.Semantic proximity Read ↗

Viral DNA polymerase mutations associated with drug resistance in human cytomegalovirus.Semantic proximity Read ↗

Differentiated Levels of Ganciclovir Resistance Conferred by Mutations at Codons 591 to 603 of the Cytomegalovirus UL97 Kinase Gene.Semantic proximity Read ↗

Cytomegalovirus UL97 kinase catalytic domain mutations that confer multidrug resistance.Semantic proximity Read ↗

Mutations in the human cytomegalovirus UL27 gene that confer resistance to maribavir.Semantic proximity Read ↗

Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet.Semantic proximity Read ↗

Identification of newly detected, drug-related HCMV UL97- and UL54-mutations using a modified plaque reduction assay.Semantic proximity Read ↗

Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial.Semantic proximity Read ↗

Antiviral Drug Resistance of Human CytomegalovirusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.