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Article

Differentiation between polymorphisms and resistance-associated mutations in human cytomegalovirus DNA polymerase.

Antimicrobial agents and chemotherapy - 1 Dec 2010

Chevillotte Meike, Ersing Ina, Mertens Thomas, von Einem Jens

Abstract excerpt

Specific mutations in the human cytomegalovirus (HCMV) DNA polymerase (pUL54) are known to confer resistance against all currently licensed drugs for treatment of HCMV infection and disease. Following the widespread use of antivirals, the occurrence of HCMV drug resistance is constantly increasing. Recently, diagnostic laboratories have started to replace phenotypic drug resistance testing with genotypic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20876378
DOI: 10.1128/AAC.00259-10
PMCID: PMC2981283

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