Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of resistance-associated HCMV UL97- and UL54-mutations and a UL97-polymporphism with impact on phenotypic drug-resistance.

Antiviral research - 1 Jul 2016

Fischer Lena, Imrich Eike, Sampaio Kerstin Laib, Hofmann Jörg, Jahn Gerhard, Hamprecht Klaus, Göhring Katharina

Abstract excerpt

BACKGROUND: Human cytomegalovirus (HCMV) drug-resistance remains of high clinical importance. While UL97-mutations can confer ganciclovir-resistance, UL54-mutations can be associated with resistance to ganciclovir, foscarnet and/or cidofovir. OBJECTIVE: Three UL97-mutations (A619V, P468Q, del597-599), three UL54-mutations (V715A, A492D, L516W) and two UL97/UL54-mutation combinations (A594TUL97+V715MUL54;...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Artificial, Bacterial
Share to Cytomegalovirus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytomegalovirus Infections

Share to Cytosine

Share to Foscarnet

Share to Ganciclovir

Share to Immunocompromised Host

Share to Organophosphonates

Source

Identifiers

PMID: 27058773
DOI: 10.1016/j.antiviral.2016.04.002

Genes

FOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of resistance-associated HCMV UL97- and UL54-mutations and a UL97-polymporphism with impact on phenotypic drug-resistance.PMID 27058773Read ↗

Identification of newly detected, drug-related HCMV UL97- and UL54-mutations using a modified plaque reduction assay.Semantic proximity Read ↗

Generation and characterization of a GCV resistant HCMV UL97-mutation and a drug sensitive UL54-mutation.Semantic proximity Read ↗

Contrasting effect of new HCMV pUL54 mutations on antiviral drug susceptibility: Benefits and limits of 3D analysis.Semantic proximity Read ↗

A new tool linking human cytomegalovirus drug resistance mutations to resistance phenotypes.Semantic proximity Read ↗

The biology of cytomegalovirus drug resistance.Semantic proximity Read ↗

Genotypic and Phenotypic Study of Antiviral Resistance Mutations in Refractory Cytomegalovirus Infection.Semantic proximity Read ↗

Human cytomegalovirus antiviral drug resistance in hematopoietic stem cell transplantation: current state of the art.Semantic proximity Read ↗

Genotypic resistance of cytomegalovirus to antivirals in hematopoietic stem cell transplant recipients from Portugal: A retrospective study.Semantic proximity Read ↗

Cytomegalovirus antiviral resistance associated with treatment induced UL97 (protein kinase) and UL54 (DNA polymerase) mutations.Semantic proximity Read ↗

Dynamics of coexisting HCMV-UL97 and UL54 drug-resistance associated mutations in patients after haematopoietic cell transplantation.Semantic proximity Read ↗

Differentiated Levels of Ganciclovir Resistance Conferred by Mutations at Codons 591 to 603 of the Cytomegalovirus UL97 Kinase Gene.Semantic proximity Read ↗

Antiviral Drug- and Multidrug Resistance in Cytomegalovirus Infected SCT PatientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.