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Article

Epidermal growth factor receptor pathway mutation and expression profiles in cervical squamous cell carcinoma: therapeutic implications.

Journal of translational medicine - 25 Jul 2015

Bumrungthai Sureewan, Munjal Kavita, Nandekar Shirish, Cooper Kumarasen, Ekalaksananan Tipaya, Pientong Chamsai, Evans Mark Francis

Abstract excerpt

BACKGROUND: Cervical squamous cell carcinoma (CSCC) is a major cause of female mortality worldwide. This study has examined epidermal growth factor receptor (EGFR) pathway markers that represent actionable pharmacological targets. METHODS: HPV16 positive CSCCs (n = 105 patients) from Madhya Pradesh, India were screened for KRAS and PIK3CA mutations by PNA-clamp real-time PCR. Immunohistochemistry (IHC) was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26209091
DOI: 10.1186/s12967-015-0611-0
PMCID: PMC4513684

Genes

EGFR
KRAS
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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