Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Oncogenic mutations of the PIK3CA gene in head and neck squamous cell carcinomas.

International journal of oncology - 1 Jan 2008

Murugan Avaniyapuram Kannan, Hong Nguyen Thi, Fukui Yasuhisa, Munirajan Arasambattu Kannan, Tsuchida Nobuo

Abstract excerpt

Phosphatidylinositol 3-kinases (PI3Ks) are heterodimeric lipid kinases that regulate cellular activities such as proliferation, survival, motility and morphology. Recent studies reported that the p110alpha (PIK3CA), catalytic subunit of PI3-kinase is somatically mutated in human cancers. Hot- spot mutations (E542K, E545K and H1047R) are reported to have higher oncogenic potential. Although PIK3CA mutations were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Squamous Cell
Share to Cell Movement

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Class I Phosphatidylinositol 3-Kinases

Share to Genes, p53

Share to Genes, ras

Share to Head and Neck Neoplasms

Share to Phosphatidylinositol 3-Kinases

Share to PTEN Phosphohydrolase

Source

Identifiers

PMID: 18097548

Genes

PTEN
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oncogenic mutations of the PIK3CA gene in head and neck squamous cell carcinomas.PMID 18097548Read ↗

Novel mutations of PIK3CA gene in head and neck squamous cell carcinoma.Semantic proximity Read ↗

Genetic alterations of the PIK3CA oncogene in human oral squamous cell carcinoma in an Indian population.Semantic proximity Read ↗

PIK3CA mutations in human solid tumors: role in sensitivity to various therapeutic approaches.Semantic proximity Read ↗

Understanding PI3K/Akt/mTOR signaling in squamous cell carcinoma: mutated PIK3CA as an example.Semantic proximity Read ↗

<i>PIK3CA</i> mutations in nasopharyngeal carcinomaSemantic proximity Read ↗

<i>PIK3CA</i> Mutations in Head and Neck Squamous Cell CarcinomaSemantic proximity Read ↗

Targeting phosphoinositide 3-kinase (PI3K) in head and neck squamous cell carcinoma (HNSCC)Semantic proximity Read ↗

The Determinants of Head and Neck Cancer: Unmasking the PI3K Pathway MutationsSemantic proximity Read ↗

Analysis of PIK3CA and Akt/protein kinase B in head and neck squamous cell carcinoma.Semantic proximity Read ↗

<i>PIK3CA</i> mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinomaSemantic proximity Read ↗

Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers.Semantic proximity Read ↗

PIK3CA, HRAS and PTEN in human papillomavirus positive oropharyngeal squamous cell carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.