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Article

High incidence of PI3K pathway gene mutations in South Indian cervical cancers.

Cancer genetics - 1 Jun 2022

Rose Mathew Maria, Dhamodharan Shankar, Revathidevi Sundaramoorthy, Chakkarappan Sundaram Reddy, Jagadeesan Mani G, Subbiah Shanmugam, Nakaoka Hirofumi, Inoue Ituro, Murugan Avaniyapuram Kannan, Munirajan Arasambattu Kannan

Abstract excerpt

INTRODUCTION: Cervical cancer is the second most common cancer in India. The phosphatidylinositol-3 kinase (PI3K) signaling is one of the most commonly activated pathways in cancer and comprises key molecules commonly targeted in cancer therapy. This study analyzed six PI3K pathway gene mutations. METHODS: We carried out targeted next-generation sequencing of six PI3K pathway genes (PIK3CA, PIK3R1, PTEN, AKT1,...

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PMID: 35568000
DOI: 10.1016/j.cancergen.2022.05.002

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