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PIK3CA mutation and CNV status and post-chemoradiotherapy survival in patients with cervical cancer.

Gynecologic oncology - 1 Sept 2020

Martell Kevin, McIntyre John B, Kornaga Elizabeth N, Chan Angela M Y, Phan Tien, Köbel Martin, Enwere Emeka K, Dean Michelle L, Ghatage Prafull, Lees-Miller Susan P, Doll Corinne M

Abstract excerpt

PURPOSE: This study aimed to describe the prognostic value of PI3K/AKT pathway mutations in a large cohort of patients with cervical cancer. EXPERIMENTAL DESIGN: Patients with pre-treatment archival specimens, diagnosed with FIGO stages IB-IVA cervical cancer between 1998 and 2014 and treated with radical, curative intent chemoradiotherapy (CRT) at a single center were identified. Mutational status was determined...

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PMID: 32653099
DOI: 10.1016/j.ygyno.2020.06.506

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