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Article

Structure of yeast Ape1 and its role in autophagic vesicle formation.

Autophagy - 1 Jan 2015

Su Ming-Yuan, Peng Wen-Hsin, Ho Meng-Ru, Su Shih-Chieh, Chang Yuan-Chih, Chen Guang-Chao, Chang Chung-I

Abstract excerpt

In Saccharomyces cerevisiae, a constitutive biosynthetic transport pathway, termed the cytoplasm-to-vacuole targeting (Cvt) pathway, sequesters precursor aminopeptidase I (prApe1) dodecamers in the form of a large complex into a Cvt vesicle using autophagic machinery, targeting it into the vacuole (the yeast lysosome) where it is proteolytically processed into its mature form, Ape1, by removal of an...

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Identifiers

PMID: 26208681
DOI: 10.1080/15548627.2015.1067363
PMCID: PMC4590589

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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