Mechanism of cargo selection in the cytoplasm to vacuole targeting pathway.

doi:10.1016/s1534-5807(02)00373-8

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Article

Mechanism of cargo selection in the cytoplasm to vacuole targeting pathway.

Developmental cell - 1 Dec 2002

Shintani Takahiro, Huang Wei-Pang, Stromhaug Per E, Klionsky Daniel J

Abstract excerpt

The proper functioning of eukaryotic organelles is largely dependent on the specific packaging of cargo proteins within transient delivery vesicles. The cytoplasm to vacuole targeting (Cvt) pathway is an autophagy-related trafficking pathway whose cargo proteins, aminopeptidase I and alpha-mannosidase, are selectively transported from the cytoplasm to the lysosome-like vacuole in yeast. This study elucidates a...

Topics

Aminopeptidases
Autophagy
Autophagy-Related Proteins
Carrier Proteins
Cell Compartmentation
Cytoplasm
Green Fluorescent Proteins
Luminescent Proteins
Mannosidases
Mutation
Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phagosomes

Protein Structure, Secondary

Protein Structure, Tertiary

Protein Transport

Receptors, Cell Surface

Recombinant Fusion Proteins

Saccharomyces cerevisiae

Source

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Identifiers

PMID: 12479808
DOI: 10.1016/s1534-5807(02)00373-8
PMCID: PMC2737732

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