Article
Studies of cargo delivery to the vacuole mediated by autophagosomes in Saccharomyces cerevisiae.
Developmental cell - 1 Dec 2002
Suzuki Kuninori, Kamada Yoshiaki, Ohsumi Yoshinori
Abstract excerpt
In the yeast Saccharomyces cerevisiae, aminopeptidase I (API), a vacuolar hydrolase, is selectively transported to the vacuole via the autophagosome. API forms a cytosol to vacuole targeting (Cvt) complex in the cytoplasm. The complex is engulfed by the autophagosome under starvation conditions. In this study, the Cvt complex is visualized as a dot in the cytoplasm by fluorescence microscopy with API-GFP. The Cvt...
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