Article
Structural basis for the specificity and catalysis of human Atg4B responsible for mammalian autophagy.
The Journal of biological chemistry - 2 Dec 2005
Sugawara Kenji, Suzuki Nobuo N, Fujioka Yuko, Mizushima Noboru, Ohsumi Yoshinori, Inagaki Fuyuhiko
Abstract excerpt
Reversible modification of Atg8 with phosphatidylethanolamine is crucial for autophagy, the bulk degradation system conserved in eukaryotic cells. Atg4 is a novel cysteine protease that processes and deconjugates Atg8. Herein, we report the crystal structure of human Atg4B (HsAtg4B) at 1.9-A resolution. Despite no obvious sequence homology with known proteases, the structure of HsAtg4B shows a classical...
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