Article

A yeast lysosomal biogenesis map uncovers the cargo spectrum of lysosomal protein targeting pathways

2021-07-25

Abstract excerpt

The lysosome is the major catabolic organelle and a key metabolic signaling center of the cell. Mutations in lysosomal proteins can have catastrophic effects, causing neurodegeneration, cancer, and age-related diseases. The vacuole is the lysosomal analog of Saccharomyces cerevisiae that harbors many conserved proteins. Vacuolar proteins reach their destination via the endosomal vacuolar protein sorting (VPS) pat...

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Literature Corpus work: 1ac4f715-3117-5afc-b858-cc9dacafd9b8
DOI: 10.1101/2021.07.24.453616

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