Article
A new class of mutants deficient in dodecamerization of aminopeptidase 1 and vacuolar transport.
The Journal of biological chemistry - 13 Apr 2001
Andrei-Selmer C, Knuppel A, Satyanarayana C, Heese C, Schu P V
Abstract excerpt
Vacuolar aminopeptidase 1 is transported to the vacuole by cytoplasmic double-membrane vesicles, the nonclassic Cvt pathway. The cytosolic protein dodecamerizes and is enclosed in a double-membrane vesicle, which is transported to and fuses with the vacuole releasing a single-membrane autophagic body into the vacuolar lumen. This is degraded and the precursor sequence of aminopeptidase 1 is removed. This pathway...
Topics
- Aminopeptidases
- Biological Transport
- Biopolymers
- Mutation
- Protein Conformation
- Vacuoles