Article
Targeted sequencing identifies associations between IL7R-JAK mutations and epigenetic modulators in T-cell acute lymphoblastic leukemia.
Haematologica - 1 Oct 2015
Vicente Carmen, Schwab Claire, Broux Michaël, Geerdens Ellen, Degryse Sandrine, Demeyer Sofie, Lahortiga Idoya, Elliott Alannah, Chilton Lucy, La Starza Roberta, Mecucci Cristina, Vandenberghe Peter, Goulden Nicholas, Vora Ajay, Moorman Anthony V, Soulier Jean, Harrison Christine J, Clappier Emmanuelle, Cools Jan
Abstract excerpt
T-cell acute lymphoblastic leukemia is caused by the accumulation of multiple oncogenic lesions, including chromosomal rearrangements and mutations. To determine the frequency and co-occurrence of mutations in T-cell acute lymphoblastic leukemia, we performed targeted re-sequencing of 115 genes across 155 diagnostic samples (44 adult and 111 childhood cases). NOTCH1 and CDKN2A/B were mutated/deleted in more than...
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