Article
IL-7 Receptor Mutations and Steroid Resistance in Pediatric T cell Acute Lymphoblastic Leukemia: A Genome Sequencing Study.
PLoS medicine - 1 Dec 2016
Li Yunlei, Buijs-Gladdines Jessica G C A M, Canté-Barrett Kirsten, Stubbs Andrew P, Vroegindeweij Eric M, Smits Willem K, van Marion Ronald, Dinjens Winand N M, Horstmann Martin, Kuiper Roland P, Buijsman Rogier C, Zaman Guido J R, van der Spek Peter J, Pieters Rob, Meijerink Jules P P
Abstract excerpt
BACKGROUND: Pediatric acute lymphoblastic leukemia (ALL) is the most common childhood cancer and the leading cause of cancer-related mortality in children. T cell ALL (T-ALL) represents about 15% of pediatric ALL cases and is considered a high-risk disease. T-ALL is often associated with resistance to treatment, including steroids, which are currently the cornerstone for treating ALL; moreover, initial steroid...
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