Article
The mutational landscape in pediatric acute lymphoblastic leukemia deciphered by whole genome sequencing.
Human mutation - 1 Jan 2015
Lindqvist Carl Mårten, Nordlund Jessica, Ekman Diana, Johansson Anna, Moghadam Behrooz Torabi, Raine Amanda, Övernäs Elin, Dahlberg Johan, Wahlberg Per, Henriksson Niklas, Abrahamsson Jonas, Frost Britt-Marie, Grandér Dan, Heyman Mats, Larsson Rolf, Palle Josefine, Söderhäll Stefan, Forestier Erik, Lönnerholm Gudmar, Syvänen Ann-Christine, Berglund Eva C
Abstract excerpt
Genomic characterization of pediatric acute lymphoblastic leukemia (ALL) has identified distinct patterns of genes and pathways altered in patients with well-defined genetic aberrations. To extend the spectrum of known somatic variants in ALL, we performed whole genome and transcriptome sequencing of three B-cell precursor patients, of which one carried the t(12;21)ETV6-RUNX1 translocation and two lacked a known...
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