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Article

The BDNF Valine 68 to Methionine Polymorphism Increases Compulsive Alcohol Drinking in Mice That Is Reversed by Tropomyosin Receptor Kinase B Activation.

Biological psychiatry - 15 Mar 2016

Warnault Vincent, Darcq Emmanuel, Morisot Nadege, Phamluong Khanhky, Wilbrecht Linda, Massa Stephen M, Longo Frank M, Ron Dorit

Abstract excerpt

BACKGROUND: The valine 66 to methionine (Met) polymorphism within the brain-derived neurotrophic factor (BDNF) sequence reduces activity-dependent BDNF release and is associated with psychiatric disorders in humans. Alcoholism is one of the most prevalent psychiatric diseases. Here, we tested the hypothesis that this polymorphism increases the severity of alcohol abuse disorders. METHODS: We generated transgenic...

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Source

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Identifiers

PMID: 26204799
DOI: 10.1016/j.biopsych.2015.06.007
PMCID: PMC4676961

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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