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Article

Chronic methamphetamine interacts with BDNF Val66Met to remodel psychosis pathways in the mesocorticolimbic proteome.

Molecular psychiatry - 1 Aug 2021

Greening David W, Notaras Michael, Chen Maoshan, Xu Rong, Smith Joel D, Cheng Lesley, Simpson Richard J, Hill Andrew F, van den Buuse Maarten

Abstract excerpt

Methamphetamine (Meth) abuse has reached epidemic proportions in many countries and can induce psychotic episodes mimicking the clinical profile of schizophrenia. Brain-derived neurotrophic factor (BDNF) is implicated in both Meth effects and schizophrenia. We therefore studied the long-term effects of chronic Meth exposure in transgenic mice engineered to harbor the human BDNFVal66Met polymorphism expressed via...

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PMID: 31822818
DOI: 10.1038/s41380-019-0617-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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