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Article

Multiple Sclerosis Risk Allele in CLEC16A Acts as an Expression Quantitative Trait Locus for CLEC16A and SOCS1 in CD4+ T Cells.

PloS one - 1 Jan 2015

Leikfoss Ingvild S, Keshari Pankaj K, Gustavsen Marte W, Bjølgerud Anja, Brorson Ina S, Celius Elisabeth G, Spurkland Anne, Bos Steffan D, Harbo Hanne F, Berge Tone

Abstract excerpt

For multiple sclerosis, genome wide association studies and follow up studies have identified susceptibility single nucleotide polymorphisms located in or near CLEC16A at chromosome 16p13.13, encompassing among others CIITA, DEXI and SOCS1 in addition to CLEC16A. These genetic variants are located in intronic or intergenic regions and display strong linkage disequilibrium with each other, complicating the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 26203907
DOI: 10.1371/journal.pone.0132957
PMCID: PMC4512731

Genes

SOCS1
DEXI
CIITA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Multiple Sclerosis Risk Allele in CLEC16A Acts as an Expression Quantitative Trait Locus for CLEC16A and SOCS1 in CD4+ T Cells.PMID 26203907Read ↗

Multiple sclerosis-associated single-nucleotide polymorphisms in CLEC16A correlate with reduced SOCS1 and DEXI expression in the thymus.Semantic proximity Read ↗

Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene.Semantic proximity Read ↗

From Identification to Characterization of the Multiple Sclerosis Susceptibility Gene CLEC16ASemantic proximity Read ↗

Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA-CLEC16A-SOCS1 gene complex.Semantic proximity Read ↗

Defining Mechanistic Links Between the Non-Coding Variant rs17673553 in CLEC16A and Lupus SusceptibilitySemantic proximity Read ↗

Exploring the CLEC16A gene reveals a MS-associated variant with correlation to the relative expression of CLEC16A isoforms in thymus.Semantic proximity Read ↗

Polymorphisms in CLEC16A and CIITA at 16p13 are associated with primary adrenal insufficiency.Semantic proximity Read ↗

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