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Article

Multiple sclerosis-associated single-nucleotide polymorphisms in CLEC16A correlate with reduced SOCS1 and DEXI expression in the thymus.

Genes and immunity - 1 Jan 2013

Leikfoss I S, Mero I-L, Dahle M K, Lie B A, Harbo H F, Spurkland A, Berge T

Abstract excerpt

Genome-wide association studies have revealed that the 16p13 chromosomal region, including CLEC16A, DEXI, CIITA and SOCS1, is associated with susceptibility to autoimmune diseases. As non-coding single-nucleotide polymorphisms (SNPs) may confer susceptibility to disease by affecting expression of nearby genes, we examined whether autoimmune-associated intronic CLEC16A SNPs (rs12708716, rs6498169 and rs7206912)...

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Source

Identifiers

PMID: 23151489
DOI: 10.1038/gene.2012.52

Genes

DEXI
SOCS1
CIITA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Multiple sclerosis-associated single-nucleotide polymorphisms in CLEC16A correlate with reduced SOCS1 and DEXI expression in the thymus.PMID 23151489Read ↗

Multiple Sclerosis Risk Allele in CLEC16A Acts as an Expression Quantitative Trait Locus for CLEC16A and SOCS1 in CD4+ T Cells.Semantic proximity Read ↗

Exploring the CLEC16A gene reveals a MS-associated variant with correlation to the relative expression of CLEC16A isoforms in thymus.Semantic proximity Read ↗

Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene.Semantic proximity Read ↗

Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA-CLEC16A-SOCS1 gene complex.Semantic proximity Read ↗

From Identification to Characterization of the Multiple Sclerosis Susceptibility Gene CLEC16ASemantic proximity Read ↗

Defining Mechanistic Links Between the Non-Coding Variant rs17673553 in CLEC16A and Lupus SusceptibilitySemantic proximity Read ↗

Polymorphisms in CLEC16A and CIITA at 16p13 are associated with primary adrenal insufficiency.Semantic proximity Read ↗

Variation within the CLEC16A gene shows consistent disease association with both multiple sclerosis and type 1 diabetes in Sardinia.Semantic proximity Read ↗

Chromosomal region 16p13: further evidence of increased predisposition to immune diseases.Semantic proximity Read ↗

Replication of CD58 and CLEC16A as genome-wide significant risk genes for multiple sclerosis.Semantic proximity Read ↗

Multiple sclerosis-associated CLEC16A controls HLA class II expression via late endosome biogenesis.Semantic proximity Read ↗

Target genes regulated by CLEC16A intronic region associated with common variable immunodeficiency.Semantic proximity Read ↗

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