Article
Chromosomal region 16p13: further evidence of increased predisposition to immune diseases.
Annals of the rheumatic diseases - 1 Jan 2010
Martínez A, Perdigones N, Cénit M C, Espino L, Varadé J, Lamas J R, Santiago J L, Fernández-Arquero M, de la Calle H, Arroyo R, de la Concha E G, Fernández-Gutiérrez B, Urcelay E
Abstract excerpt
OBJECTIVE: Genome-wide studies have identified the chromosomal region 16p13 in the susceptibility to type 1 diabetes (T1D) and multiple sclerosis (MS). This region includes the CLEC16A/KIAA0350 gene and an adjacent gene, MHC2TA (MHC class II transactivator), previously associated with susceptibility to MS and rheumatoid arthritis (RA). The role of CLEC16A polymorphisms in the pathogenesis of T1D, MS and RA and...
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