Article
Exploring the CLEC16A gene reveals a MS-associated variant with correlation to the relative expression of CLEC16A isoforms in thymus.
Genes and immunity - 1 Apr 2011
Mero I-L, Ban M, Lorentzen Å R, Smestad C, Celius E G, Sæther H, Saeedi H, Viken M K, Skinningsrud B, Undlien D E, Aarseth J, Myhr K-M, Granum S, Spurkland A, Sawcer S, Compston A, Lie B A, Harbo H F
Abstract excerpt
Genomewide association studies have implicated the CLEC16A gene in several autoimmune diseases, including multiple sclerosis (MS) and type 1 diabetes. However, the most associated single-nucleotide polymorphism (SNP) varies, and causal variants are still to be defined. In MS, two SNPs in partial linkage disequilibrium with each other, rs6498169 and rs12708716, have been validated at genomewide significance level....
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