Article
Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA-CLEC16A-SOCS1 gene complex.
Human molecular genetics - 1 Sept 2011
Zuvich Rebecca L, Bush William S, McCauley Jacob L, Beecham Ashley H, De Jager Philip L, Ivinson Adrian J, Compston Alastair, Hafler David A, Hauser Stephen L, Sawcer Stephen J, Pericak-Vance Margaret A, Barcellos Lisa F, Mortlock Douglas P, Haines Jonathan L
Abstract excerpt
Multiple sclerosis (MS) is a neurodegenerative, autoimmune disease of the central nervous system, and numerous studies have shown that MS has a strong genetic component. Independent studies to identify MS-associated genes have often indicated multiple signals in physically close genomic regions, although by their proximity it is not always clear if these data indicate redundant or truly independent genetic...
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