Article
Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene.
Human molecular genetics - 15 Jan 2012
Davison Lucy J, Wallace Chris, Cooper Jason D, Cope Nathan F, Wilson Nicola K, Smyth Deborah J, Howson Joanna M M, Saleh Nada, Al-Jeffery Abdullah, Angus Karen L, Stevens Helen E, Nutland Sarah, Duley Simon, Coulson Richard M R, Walker Neil M, Burren Oliver S, Rice Catherine M, Cambien Francois, Zeller Tanja, Munzel Thomas, Lackner Karl, Blakenberg Stefan, Fraser Peter, Gottgens Berthold, Todd John A, Attwood Tony, Belz Stephanie, Braund Peter, Cambien François, Cooper Jason, Crisp-Hihn Abi, Diemert Patrick, Deloukas Panos, Foad Nicola, Erdmann Jeanette, Goodall Alison H, Gracey Jay, Gray Emma, Williams Rhian G, Heimerl Susanne, Hengstenberg Christian, Jolley Jennifer, Krishnan Unni, Lloyd-Jones Heather, Lugauer Ingrid, Lundmark Per, Maouche Seraya, Moore Jasbir S, Muir David, Murray Elizabeth, Nelson Chris P, Neudert Jessica, Niblett David, O'Leary Karen, Ouwehand Willem H, Pollard Helen, Rankin Angela, Rice Catherine M, Sager Hendrik, Samani Nilesh J, Sambrook Jennifer, Schmitz Gerd, Scholz Michael, Schroeder Laura, Schunkert Heribert, Syvannen Ann-Christine, Tennstedt Stefanie, Wallace Chris
Abstract excerpt
The chromosome 16p13 region has been associated with several autoimmune diseases, including type 1 diabetes (T1D) and multiple sclerosis (MS). CLEC16A has been reported as the most likely candidate gene in the region, since it contains the most disease-associated single-nucleotide polymorphisms (SNPs), as well as an imunoreceptor tyrosine-based activation motif. However, here we report that intron 19 of CLEC16A,...
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