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Article

Complex long-distance effects of mutations that confer linezolid resistance in the large ribosomal subunit.

Nucleic acids research - 18 Sept 2015

Fulle Simone, Saini Jagmohan S, Homeyer Nadine, Gohlke Holger

Abstract excerpt

The emergence of multidrug-resistant pathogens will make current antibiotics ineffective. For linezolid, a member of the novel oxazolidinone class of antibiotics, 10 nucleotide mutations in the ribosome have been described conferring resistance. Hypotheses for how these mutations affect antibiotics binding have been derived based on comparative crystallographic studies. However, a detailed description at the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26202966
DOI: 10.1093/nar/gkv729
PMCID: PMC4652758

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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