Article
Probing the Molecular Mechanism of Rifampin Resistance Caused by the Point Mutations S456L and D441V on Mycobacterium tuberculosis RNA Polymerase through Gaussian Accelerated Molecular Dynamics Simulation.
Antimicrobial agents and chemotherapy - 23 Jun 2020
Zhang Qianqian, Tan Shuoyan, Xiao Tong, Liu Hongli, Shah Syed Jawad Ali, Liu Huanxiang
Abstract excerpt
Rifampin is the first-line antituberculosis drug, with Mycobacterium tuberculosis RNA polymerase as the molecular target. Unfortunately, M. tuberculosis strains that are resistant to rifampin have been identified in clinical settings, which limits its therapeutic effects. In clinical isolates, S531L and D516V (in Escherichia coli) are two common mutated codons in the gene rpoB, corresponding to S456L and D441V in...
Topics
- Antitubercular Agents
- Bacterial Proteins
- DNA-Directed RNA Polymerases
- Drug Resistance, Bacterial
- Molecular Dynamics Simulation
- Mutation
- Mycobacterium tuberculosis
- Point Mutation
- Rifampin