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Article

The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning

29 Aug 2008

Abstract excerpt

The oxazolidinones represent the first new class of antibiotics to enter into clinical usage within the past 30 years, but their binding site and mechanism of action has not been fully characterized. We have determined the crystal structure of the oxazolidinone linezolid bound to the Deinococcus radiodurans 50S ribosomal subunit. Linezolid binds in the A site pocket at the peptidyltransferase center of the...

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PMID: 18757750
DOI: 10.1073/pnas.0804276105

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