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Article

Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance.

Antimicrobial agents and chemotherapy - 1 Nov 2010

Long Katherine S, Munck Christian, Andersen Theis M B, Schaub Maria A, Hobbie Sven N, Böttger Erik C, Vester Birte

Abstract excerpt

The oxazolidinone antibiotic linezolid targets the peptidyl transferase center (PTC) on the bacterial ribosome. Thirteen single and four double 23S rRNA mutations were introduced into a Mycobacterium smegmatis strain with a single rRNA operon. Converting bacterial base identity by single mutations at positions 2032, 2453, and 2499 to human cytosolic base identity did not confer significantly reduced...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 20696869
DOI: 10.1128/AAC.00644-10
PMCID: PMC2976117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance.PMID 20696869Read ↗

Resistance to Linezolid Caused by Modifications at Its Binding Site on the RibosomeSemantic proximity Read ↗

Resistance mutations in 23 S rRNA identify the site of action of the protein synthesis inhibitor linezolid in the ribosomal peptidyl transferase center.Semantic proximity Read ↗

Ribosomal and non-ribosomal resistance to oxazolidinones: species-specific idiosyncrasy of ribosomal alterations.Semantic proximity Read ↗

Single 23S rRNA mutations at the ribosomal peptidyl transferase centre confer resistance to valnemulin and other antibiotics in Mycobacterium smegmatis by perturbation of the drug binding pocket.Semantic proximity Read ↗

Linezolid and Tiamulin Cross-Resistance in Staphylococcus aureus Mediated by Point Mutations in the Peptidyl Transferase CenterSemantic proximity Read ↗

Single and dual mutations at positions 2058, 2503 and 2504 of 23S rRNA and their relationship to resistance to antibiotics that target the large ribosomal subunit.Semantic proximity Read ↗

Resistance to linezolid in Staphylococcus aureus by mutation, modification, and acquisition of genes.Semantic proximity Read ↗

Structural Basis for Linezolid Binding Site Rearrangement in the Staphylococcus aureus Ribosome.Semantic proximity Read ↗

Complex long-distance effects of mutations that confer linezolid resistance in the large ribosomal subunit.Semantic proximity Read ↗

Structural basis for cross-resistance to ribosomal PTC antibioticsSemantic proximity Read ↗

Functional interactions within 23S rRNA involving the peptidyltransferase center.Semantic proximity Read ↗

The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioningSemantic proximity Read ↗

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