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Article

Association of MUTYH and MSH6 germline mutations in colorectal cancer patients.

Familial cancer - 1 Jan 2009

Giráldez María Dolores, Balaguer Francesc, Caldés Trinidad, Sanchez-de-Abajo Ana, Gómez-Fernández Nuria, Ruiz-Ponte Clara, Muñoz Jenifer, Garre Pilar, Gonzalo Victoria, Moreira Leticia, Ocaña Teresa, Clofent Joan, Carracedo Angel, Andreu Montserrat, Jover Rodrigo, Llor Xavier, Castells Antoni, Castellví-Bel Sergi

Abstract excerpt

Colorectal cancer (CRC) risk associated with germline monoallelic MUTYH mutations remains controversial, although a slightly increased risk for this disease has been suggested. MUTYH and MSH6 proteins act in cooperation during the DNA repair process. Based on this interaction, it was hypothesized...

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Source

Identifiers

PMID: 19685280
DOI: 10.1007/s10689-009-9282-4

Genes

MUTYH
MSH6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19685280-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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