Colorectal and other cancer risks for carriers and noncarriers from families with a DNA mismatch repair gene mutation: a prospective cohort study.

doi:10.1200/JCO.2011.39.5590

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Article

Colorectal and other cancer risks for carriers and noncarriers from families with a DNA mismatch repair gene mutation: a prospective cohort study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Mar 2012

Win Aung Ko, Young Joanne P, Lindor Noralane M, Tucker Katherine M, Ahnen Dennis J, Young Graeme P, Buchanan Daniel D, Clendenning Mark, Giles Graham G, Winship Ingrid, Macrae Finlay A, Goldblatt Jack, Southey Melissa C, Arnold Julie, Thibodeau Stephen N, Gunawardena Shanaka R, Bapat Bharati, Baron John A, Casey Graham, Gallinger Steven, Le Marchand Loïc, Newcomb Polly A, Haile Robert W, Hopper John L, Jenkins Mark A

Abstract excerpt

PURPOSE: To determine whether cancer risks for carriers and noncarriers from families with a mismatch repair (MMR) gene mutation are increased above the risks of the general population. PATIENTS AND METHODS: We prospectively followed a cohort of 446 unaffected carriers of an MMR gene mutation (MLH1, n = 161; MSH2, n = 222; MSH6, n = 47; and PMS2, n = 16) and 1,029 their unaffected relatives who did not carry a...

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Identifiers

PMID: 22331944
DOI: 10.1200/JCO.2011.39.5590
PMCID: PMC3341109

Genes

MLH1
MSH2
MSH6
PMS2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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