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Article

Clinicopathological and genotypic characteristics of colorectal cancer patients carrying a germline MUTYH mutation.

Revista da Associacao Medica Brasileira (1992) - 1 Jan 2026

Guzelis Ismail, Gasimli Roya, Subaşıoğlu Aslı, Sari Aysegul

Abstract excerpt

OBJECTIVE: Approximately 5-10% of the cases with colorectal cancers have a hereditary cancer syndrome. MUTYH is a DNA base excision repair gene, and its mutation can induce the development of polyposis and colorectal cancer. Additionally, MUTYH repair gene may interact with the DNA mismatch repair system. The aim of this study was to investigate the clinicopathological features of colorectal cancer cases carrying...

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Source

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Identifiers

PMID: 42018848
DOI: 10.1590/1806-9282.20251212
PMCID: PMC13105420

Genes

MUTYH
MSH2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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