Are the common genetic variants associated with colorectal cancer risk for DNA mismatch repair gene mutation carriers?

doi:10.1016/j.ejca.2013.01.029

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Article

Are the common genetic variants associated with colorectal cancer risk for DNA mismatch repair gene mutation carriers?

European journal of cancer (Oxford, England : 1990) - 1 May 2013

Win Aung Ko, Hopper John L, Buchanan Daniel D, Young Joanne P, Tenesa Albert, Dowty James G, Giles Graham G, Goldblatt Jack, Winship Ingrid, Boussioutas Alex, Young Graeme P, Parry Susan, Baron John A, Duggan David, Gallinger Steven, Newcomb Polly A, Haile Robert W, Le Marchand Loïc, Lindor Noralane M, Jenkins Mark A

Abstract excerpt

BACKGROUND: Genome-wide association studies have identified at least 15 independent common genetic variants associated with colorectal cancer (CRC) risk. The aim of this study was to investigate whether 11 of these variants are associated with CRC risk for carriers of germline mutations in DNA mismatch repair (MMR) genes. METHODS: A total of 927 MMR gene mutation carriers (360 MLH1, 442 MSH2, 85 MSH6 and 40 PMS2)...

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Identifiers

PMID: 23434150
DOI: 10.1016/j.ejca.2013.01.029
PMCID: PMC3625445

Genes

MLH1
MSH2
MSH6
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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