Article
MUTYH and the mismatch repair system: partners in crime?
Human genetics - 1 Mar 2006
Niessen Renée C, Sijmons Rolf H, Ou J, Olthof Sandra G M, Osinga Jan, Ligtenberg Marjolijn J, Hogervorst Frans B L, Weiss Marjan M, Tops Carli M J, Hes Frederik J, de Bock Geertruida H, Buys Charles H C M, Kleibeuker Jan H, Hofstra Robert M W
Abstract excerpt
Biallelic germline mutations of MUTYH-a gene encoding a base excision repair protein-are associated with an increased susceptibility of colorectal cancer. Whether monoallelic MUTYH mutations also increase cancer risk is not yet clear, although there is some evidence suggesting a slight increase of risk. As the MUTYH protein interacts with the mismatch repair (MMR) system, we hypothesised that the combination of a...
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