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Article

Ultradeep Sequencing for Detection of Quasispecies Variants in the Major Hydrophilic Region of Hepatitis B Virus in Indonesian Patients.

Journal of clinical microbiology - 1 Oct 2015

Yamani Laura Navika, Yano Yoshihiko, Utsumi Takako, Juniastuti, Wandono Hadi, Widjanarko Doddy, Triantanoe Ari, Wasityastuti Widya, Liang Yujiao, Okada Rina, Tanahashi Toshihito, Murakami Yoshiki, Azuma Takeshi, Soetjipto, Lusida Maria Inge, Hayashi Yoshitake

Abstract excerpt

Quasispecies of hepatitis B virus (HBV) with variations in the major hydrophilic region (MHR) of the HBV surface antigen (HBsAg) can evolve during infection, allowing HBV to evade neutralizing antibodies. These escape variants may contribute to chronic infections. In this study, we looked for MHR variants in HBV quasispecies using ultradeep sequencing and evaluated the relationship between these variants and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26202119
DOI: 10.1128/JCM.00602-15
PMCID: PMC4572547

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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