Article
The prevalence of mutations in the major hydrophilic region of the surface antigen of hepatitis B virus varies with subgenotype.
Epidemiology and infection - 1 Dec 2015
Wang X Y, Harrison T J, He X, Chen Q Y, Li G J, Liu M H, Li H, Yang J Y, Fang Z L
Abstract excerpt
Mutations in the major hydrophilic region (MHR) of the surface antigen of hepatitis B virus (HBV) may result in vaccine escape, failure of immunotherapy and antiviral resistance. These mutants may be transmitted and constitute a public health threat. We aimed to determine the prevalence of MHR mutations of HBV in areas of high endemicity in Guangxi, China. HBV surface gene was analysed from 278 HBsAg-positive...
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