Article
Genetic diversity of hepatitis B virus quasispecies in different biological compartments reveals distinct genotypes.
Scientific reports - 9 Oct 2023
do Lago Bárbara Vieira, Bezerra Cristianne Sousa, Moreira Daniel Andrade, Parente Thiago Estevam, Portilho Moyra Machado, Pessôa Rodrigo, Sanabani Sabri Saeed, Villar Livia Melo
Abstract excerpt
The selection pressure imposed by the host immune system impacts hepatitis B virus (HBV) quasispecies variability. This study evaluates HBV genetic diversity in different biological fluids. Twenty paired serum, oral fluid, and DBS samples from chronic HBV carriers were analyzed using both Sanger and next generation sequencing (NGS). The mean HBV viral load in serum was 5.19 ± 4.3 log IU/mL (median 5.29, IQR...
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