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Article

Characterization of mutations in hepatitis B virus DNA isolated from Japanese HBsAg-positive blood donors in 2021 and 2022.

Archives of virology - 18 Apr 2024

Sedohara Ayako, Takahashi Kazuaki, Arai Keiko, Arizono Kotaro, Tuvshinjargal Khulan, Saito Makoto, Nakahara Fumio, Tsutsumi Takeya, Ikeuchi Kazuhiko, Adachi Eisuke, Yotsuyanagi Hiroshi

Abstract excerpt

Missense mutations in certain small envelope proteins diminish the efficacy of antibodies. Consequently, tracking the incidence and types of vaccine-escape mutations (VEMs) was crucial both before and after the introduction of universal hepatitis B vaccination in Japan in 2016. In this study, we isolated hepatitis B virus (HBV) DNA from 58 of 169 hepatitis B surface antigen (HBsAg)-positive blood samples from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38632180
DOI: 10.1007/s00705-024-06016-4
PMCID: PMC11023964

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