Article
Different Variants in Reverse Transcriptase Domain Determined by Ultra-deep Sequencing in Treatment-naïve and Treated Indonesian Patients Infected with Hepatitis B Virus.
The Kobe journal of medical sciences - 16 Jun 2016
Wasityastuti Widya, Yano Yoshihiko, Widasari Dewiyani Indah, Yamani Laura Navika, Ratnasari Neneng, Heriyanto Didik Setyo, Okada Rina, Tanahashi Toshihito, Murakami Yoshiki, Azuma Takeshi, Hayashi Yoshitake
Abstract excerpt
A nucleos(t)ide analog (NA) is the common antiviral drug available for directly treating hepatitis B virus (HBV) infection. However, its application has led to the emergence of NA-resistant mutations mostly in a conserved region of the reverse transcriptase domain of HBV polymerase. Harboring NA-resistant mutations decreases drug effectiveness and increases the frequency of end-stage liver disease. The invention...
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