Ultra-deep sequencing reveals high prevalence and broad structural diversity of hepatitis B surface antigen mutations in a global population.

doi:10.1371/journal.pone.0172101

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Article

Ultra-deep sequencing reveals high prevalence and broad structural diversity of hepatitis B surface antigen mutations in a global population.

PloS one - 1 Jan 2017

Gencay Mikael, Hübner Kirsten, Gohl Peter, Seffner Anja, Weizenegger Michael, Neofytos Dionysios, Batrla Richard, Woeste Andreas, Kim Hyon-Suk, Westergaard Gaston, Reinsch Christine, Brill Eva, Thu Thuy Pham Thi, Hoang Bui Huu, Sonderup Mark, Spearman C Wendy, Pabinger Stephan, Gautier Jérémie, Brancaccio Giuseppina, Fasano Massimo, Santantonio Teresa, Gaeta Giovanni B, Nauck Markus, Kaminski Wolfgang E

Abstract excerpt

The diversity of the hepatitis B surface antigen (HBsAg) has a significant impact on the performance of diagnostic screening tests and the clinical outcome of hepatitis B infection. Neutralizing or diagnostic antibodies against the HBsAg are directed towards its highly conserved major hydrophilic region (MHR), in particular towards its "a" determinant subdomain. Here, we explored, on a global scale, the genetic...

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PMID: 28472040
DOI: 10.1371/journal.pone.0172101
PMCID: PMC5417417

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