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Article

Cellular and Extracellular Matrix Basis for Heterogeneity in Mitral Annular Contraction.

Cardiovascular engineering and technology - 1 Jun 2015

Stephens Elizabeth H, Fahrenholtz Monica M, Connell Patrick S, Timek Tomasz A, Daughters George T, Kuo Joyce J, Patton Aaron M, Ingels Neil B, Miller D Craig, Grande-Allen K Jane

Abstract excerpt

PURPOSE: Regional heterogeneity in mitral annular contraction, which is generally ascribed to the fibrous vs. muscular annular composition, ensures proper leaflet motion and timing of coaptation. It is unknown whether the fibroblast-like cells in the annulus modulate this heterogeneity, even though valvular interstitial cells (VICs) can be mechanically "activated." METHODS: Fourteen sheep underwent implantation...

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Source

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Identifiers

PMID: 26195991
DOI: 10.1007/s13239-014-0209-3
PMCID: PMC4505373

Genes

LAT
MMP13

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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